College football doesn't miss out on an opportunity to have a weekend to itself with no NFL games. As has become a custom, Week 1 of the 2021 college football schedule is loaded with quantity and quality, as Power Five matchups will take place from now until Labor Day on Monday, Sep. 6. The headline matchup will feature Clemson vs. Georgia, as the schools separated by just 75 miles will play for the first time in seven years. Other top college football games include defending champion Alabama visiting Miami on Saturday, while Notre Dame takes on Florida State on Sunday.

If you're looking to nail your college football picks, you'll need to know the college football odds and who to back straight-up and against the spread. Keeping up with over 100 FBS teams and knowing the matchups can be a huge challenge since dozens of matchups unfold each weekend. But if you're up for it, CBS Sports has the perfect game to keep you locked in all season long. 

Compete for $100,000 or start a pool with friends

It's time to raise the stakes with CBS Sports College Pick'em. Join the challenge to compete for the $100,000 jackpot and guaranteed cash prizes each week or start a customizable pool to compete against your friends.

You can win the $100,000 jackpot each week for hitting the full slate and tiebreakers. Even if no one hits the jackpot, CBS Sports is giving away a guaranteed $1,000 to the winner each week. In addition, the player with the most correct picks at the end of the season gets a guaranteed $5,000.

If you're looking to start a pick'em pool with your friends, family or colleagues, group settings include a variety of games suitable for every fan, including straight up-pick or against the spread picks. 

On the college side, you can choose your own slate of games or default to CBS Sports' top games. You can also choose whether to include conference championship week. You can play on your desktop or on the CBS Sports app, so sign up here today. 

Get football picks for every game from a proven college football model

We'll give you one team to consider backing during the college football's Week 1 schedule. SportsLine's advanced computer model, which simulates every FBS college football game 10,000 times, is predicting a 23-18 upset for No. 18 Iowa over No. 17 Indiana in a pivotal Big Ten contest.

Both squads finished 6-2 last year, though no team in the Big Ten finished the year stronger than the Hawkeyes. After dropping its first two games, Iowa won the final six contests with an average margin of victory of 21.8 points. Meanwhile, Indiana lost two of its last four games, one of which came before QB Michael Penix Jr. was injured.

SportsLine's model sees the Hawkeyes leaning on their ground game, particularly All-Big Ten RB Tyler Goodson. The coaches realized he was the key to the team's success as the 2020 season went on, as Goodson averaged 60 rushing yards in Iowa's two losses but 107 yards in its six wins. The model predicts he'll reach the 100-yard threshold while the Iowa defense also creates two turnovers. It not only has Iowa winning outright, but also covering the 3.5-point spread in over 50 percent of simulations.

Make college football pool picks at CBS Sports

Show your skills, beat your friends and coworkers, and take home guaranteed prize money. Create a pool, get your friends involved, and keep the competition going all season long.